Mushroom Blog

Hericium erinaceus and its effect on Parkinson's disease: scientific evidence

Hericium erinaceus is not just a mushroom with medicinal properties, but a powerful natural remedy for maintaining the health of the nervous system. Every day, scientists in different parts of the world continue to work on studying the mechanisms of action of Hericium erinaceus on neurodegenerative diseases, such as Parkinson's disease (PD).Parkinson's disease is a slowly progressive neurological disease and is one of the most common motor disorders in adulthood around the world. Modern medicine does not have a clear answer how to stop the progression of the disease, and treatment is reduced to correction of endogenous dopamine deficiency There are already many studies that confirm that Hericium erinaceus can have a positive effect on patients with Parkinson's disease. These studies show that active fungal compounds can help protect neurons, reduce oxidative stress and improve movement function.So, let's consider in more detail the studies that were conducted on living organisms (in our case, on mice):One study was conducted in collaboration with the Department of Pathology, Chang Gung Memorial Hospital, Taiwan, and published in the journal Antioxidants 2020. The aim of this study was to evaluate the effects of erinacin A on neuroprotection.Erinacin A stimulates the synthesis of nerve growth factor (NGF) and activates signal pathways of neurons survival. Results showed a significant decrease in neurons' death and improvement of brain cells.Another study was conducted on Taiwan by a team at the Institute of Biotechnology and Pharmaceutical Studies in collaboration with Jowin Biophorma Inc. These studies have shown:Stimulation of NGF synthesis: Erinacins contained in Hericium erinaceus significantly increase the production of nerve growth factor (NGF), which promotes the repair and protection of neurons.Increase in dopamine: in the course of animal experiments, it was found that the level of dopamine in the brain of mice increased by 20% at a minimum dose and by 70% at a maximum dose of fungus extract.The number of tyrosine hydroxylase-positive neurons: Tyrosine hydroxylase is an enzyme responsible for the synthesis of dopamine. After taking Hericium erinaceus, the number of tyrosine hydroxylase-positive neurons increased from 18% to 100%, depending on the dose.Reduction of dead neurons: as a result of treatment Hericium erinaceus was found that the number of dead neurons decreased by 14-22%.The decrease in oxidative stress: the formation of reactive forms of oxygen (ROS), which cause cell damage, decreased by 30%, which indicates a strong antioxidant effect of the fungus.Improvement of motor functions: subjects have a significant improvement of motor functions in experimental animals. Symptoms such as tremor, muscle rigidity and problems with coordination of movements have decreased significantly after taking fungus extracts.The results of the studies have noted that Erinacin A activates the protective mechanisms of cells, protects neurons from death and stimulates their recovery, reduces the activity of toxic molecules that cause inflammation and damage to brain cells.These processes help stop the destruction of dopaminergic neurons responsible for movement control, and reduce the symptoms of Parkinson's disease.If you or your loved ones are facing problems related to Parkinson's disease, or are looking for a way to support the health of the nervous system, pay attention to Hericium erinaceus. This mushroom can become a powerful ally in the fight for brain health.You can also buy them in our store.1.<a href='https://amanitamuscariastore.online/shop/liones-mane/'>lion's mane fruits</a>2.<a href='https://amanitamuscariastore.online/shop/liones-mane-capsules/'>The lion's mane capsules</a>3.<a href='https://amanitamuscariastore.online/shop/liones-mane-tincture/'>lion's mane extract</a>

Recovery after a stroke with Hericium erinaceus

Stroke is a serious neurological disease that occurs when blood circulation in part of the brain stops, which leads to damage or death of brain cells. Depending on which part of the brain is affected, stroke can cause a variety of symptoms: from partial or complete loss of mobility of one side of the body What happens during a stroke?During a stroke, the brain area loses blood supply due to the lock or rupture Most often, a stroke affects such functions as movement, speech, memory, and the ability to learn. Depending on the degree and localization of the damage, a person may lose the ability to move his limbs, speak, understand language, or remember elementary things.Rehabilitation after a strokeAfter a stroke, patients need long-term rehabilitation. The recovery process includes physical therapy to help restore motor skills, speech therapy to restore speech, cognitive therapy to restore memory and thinking. Rehabilitation also includes psychological support, as depression and anxiety often accompany stroke patients However, even after intensive rehabilitation, many patients face serious problems such as partial or complete loss of mobility, cognitive disorders, difficulties with speech and change in behavior. The consequences significantly reduce the quality of life and require constant support and care.Hericium erinaceus: How does it help brain recovery after stroke?One of the promising natural remedies to maintain after a stroke is Hericium erinaceus. This fungus is known for its powerful neuroprotective properties and the ability to stimulate nerve cell recovery.The main active substance in the mycelium Hericium erinaceus is eryinacin A. The compound stimulates the production of neurotrophic nerve growth factor (NGF), which is necessary for the survival and restoration of neurons. How does erinacin A work?Stimulation of NGF production: Erinacin A increases the level of NGF in the brain, which promotes the repair of neurons. This is a key factor, because NGF not only helps repair damaged cells, but also stimulates the growth of new nerve fibers.Reducing inflammation: A stroke causes significant inflammation in the brain, which can lead to further tissue damage. Erinacin A reduces the level of pro-inflammatory cytokines such as IL-1β, IL-6 and TNF-α, which helps to reduce the inflammatory process in the brain.Protection against oxidative stress: A stroke causes the formation of large amounts of reactive oxygen species (ROS), which lead to oxidative stress and subsequent damage to neurons. Erinacin A helps to reduce the level of ROS, protecting brain cells from further damage.Improved cognitive function: Due to its properties, Hericium erinaceus helps to improve cognitive function after a stroke. Studies show that regular consumption of Hericium erinaceus mycelium can improve memory, attention and learning ability.A rat study conducted in Taiwan and published in the journal Behavioral Neurology in 2018 showed impressive results.After the use of Hericium erinaceus, enriched with erinacin A, in rats with a stroke, a decrease in the volume of the infarcted area of the brain was observed by 22% at a dose of 50 mg/kg and by 44% at a dose of 300 mg/kg. This indicates a significant reduction of brain damage compared to the control In addition, the study showed that after treatment, rats experienced significantly better neuronal survival, reduced apoptosis (programmed cell death), and improved overall brain health.Another important aspect is that Hericium erinaceus is absolutely safe for consumption. The research has shown that even at high doses, no side effects were observed. This makes it an ideal remedy for prolonged use to maintain brain health and recovery from stroke.Stroke is a serious test for any person, but there are natural remedies that can help significantly recover.Enriched with Erinacin A Hericium Erinaceus extract, due to its unique properties, can be an important element of your rehabilitation. It can improve the recovery of neurons, reduce inflammation and protect the brain from further damage.You can also buy them in our store.1.<a href='https://amanitamuscariastore.online/shop/liones-mane/'>Lion mane fruits</a>2.<a href='https://amanitamuscariastore.online/shop/liones-mane-capsules/'>lion's mane capsules</a>3.<a href='https://amanitamuscariastore.online/shop/liones-mane-tincture/'>lion's mane extract</a>

Red amanita: Recovery after a stroke

Red amanita (Amanita muscaria) is known to many thanks to its bright appearance, but few people know that this mushroom can help in the treatment of serious diseases, in particular, recovery after a stroke. Thanks to its biologically active compounds, the red amanita mushroom is becoming the object of scientific research all over the world.A stroke is a dangerous condition in which the blood supply to the brain is disrupted, which can lead to serious damage to the brain tissue. After a stroke, many patients face problems related to cognitive functions, motor skills and other important aspects of health.Modern medicine is constantly looking for new remedies in rehabilitation after this dangerous condition, and fly agaric red can be an important part of these innovations.The main active compounds of red fly agaric are musciolus and ibotenic acid. The most interesting is Muscimol, which is a strong agonist of GABA receptors (gamma-aminobutyric acid)-the main inhibitory neurotransmitter in our brain. Because glutamate is an excitatory neurotransmitter - it damages brain cells in excess. Muscimol helps to balance this process, reducing the risk of further damage.According to a study, under the guidance of Professor Richard Green and scientists from the United Kingdom and New Zealand, and published in Neuropharmacology in 2000, Muscimol was a neuroprotector that contributes to a significant improvement in the state of stroke.During experiments on animals, it was recorded that the introduction of muscimol after an ischemic stroke reduces brain tissue damage by 37% compared to the control group.In addition, there was a significant improvement in cognitive functions and a faster recovery of motor skills.In the Amanita Muscaria, a fly agaric has improved such indicators as:Histological changes — analysis of brain tissue damage after an ischemic attack. The introduction of muscimol led to a significant decrease in the degree of damage to neurons, which confirmed the neuroprotective properties of this substance.Biochemical changes - there was a decrease in glutamate output, the main excitatory neurotransmitter, which plays a key role in cell damage during stroke. This reduces the further deterioration of brain tissue.Motor functions - after treatment of the musicmole, the animal showed faster recovery of motor skills. This is an important indicator in rehabilitation after stroke, as many patients face difficulties in performing even the simplest movements.The water content in the tissues is a reduction in brain swelling after the administration of muscimol. Brain tissue swelling is one of the biggest threats after a stroke, which can significantly worsen the patient's general condition and complicate recovery. Thanks to muscimol, this dangerous process is significantly reduced, which helps to avoid additional complications.Another study conducted at Kyoto Prefectural University of Medicine in Japan found that muscimol significantly reduced neuronal damage caused by over-activation of NMDA receptors – receptors that are particularly important for learning, memory and nervous system development.This study was published in 1993 in the journal "Journal of Neurochemistry". On the course of experiment, neuroni of mice was exposed to toxic NMDA (N-methyl-D-aspartate), which causes cell death, similar to the process that occurs during a stroke in the brain stroke Muscimol was able to reduce the leakage of lactate dehydrogenase (LDH), a marker of cell damage, by 50% compared to the control group. Also, in the presence of muscimol, the number of damaged cells was reduced by almost half.According to research, muscimol activates GABA receptors, which leads to hyperpolarization of neurons, that is, a decrease in their excitability. This, in turn, reduces the entry of calcium into cells, the main cause of damage to neurons during a stroke. This protective mechanism can help reduce neuronal damage and You can also buy them in our store.1.<a href='https://amanitamuscariastore.online/shop/amanita-muscaria-premium/'>Amanita fruits</a>2.<a href='https://amanitamuscariastore.online/shop/amanita-muscaria-capsules/'>Toadstool capsules</a>3.<a href='https://amanitamuscariastore.online/shop/amanita-muscaria-tincture/'>Fly agaric extract</a>4.<a href='https://amanitamuscariastore.online/shop/amanita-muscaria-powder/'>The fly agaric</a>

Trametes Versicolor takes care of your skin

Trametes versicolor is a well-known medicinal mushroom that is widely used both in medicine and in cosmetology due to its antioxidant and anti-inflammatory properties.Recent studies have shown that polysacharopeptides (PSP), isolated from the tube of colorful, can protect human skin from the harmful effects of free radicals and inflammatory processes, significantly improving the condition of the skin, reducing the effects of ultraviolet radiation and oxide stress.Skin is the largest organ of the body, one of the main functions of which is to protect the body from harmful substances. In recent years, physical damage caused by ultraviolet radiation, air pollution and toxic chemicals has led to an increase in the number of free radicals in the body.In addition, various environmental factors also lead to excessive production of active forms of oxygen (AFC), which causes progressive oxidative damage and ultimately cell death. This is closely related to human diseases such as skin aging, inflammation and cancer.In a study conducted in Taiwan and published in the Journal of Cosmetic Dermatology in 2019, scientists studied the effects of PSP on human skin cells (HaCaT).And the results demonstrate that the enzymatic hydrolyzates of PSP obtained from the mulberry can protect human skin from oxidative stress and inflammation caused by free radicals in human skin.Scientists have documented key improvements in skin healthIncrease in the viability of skin cells.Reduction of skin inflammation.Activation of antioxidant protection.Protection against free radicals.Decreased NF-κB activity (responsible for activating genes that cause inflammation).Suppression of stress reactions of the skin.Thanks to trametes versicolor, there were: an increase in cell viability by 18%, a decrease in inflammation by 25% and an improvement in the overall condition of the skin by 15-20%.The total time of the experiment was about 28 hours, during which the first results were obtained in terms of increasing cell viability and reducing inflammatory processes. This shows that even in a short period of time in laboratory conditions, the positive effect of the extract on skin cells can be seen.Of course, for real conditions on human skin and for a long-lasting effect, a longer period of use is usually required. The first results appear after 2-3 weeks of use - the overall tone of the skin will improve, inflammation will decrease.This study demonstrates that trametes Versicolor extract is a valuable ingredient for cosmetics, an indispensable helper in combating signs of aging, inflammation and harmful effects of the environment.It should be noted that the most effective will always be a comprehensive approach: internal intake of extract and external use of a gel with a tinder.You can also buy them in our store.1.<a href='https://amanitamuscariastore.online/shop/turkey-tails-fruits/'>trametes versicolor fruits</a>2.<a href='https://amanitamuscariastore.online/shop/turkey-tails-tincture/'>Trametes Versicolor Expestract</a>

Fly agaric red: natural antistress and its benefits for the nervous system

A constant feeling of danger, uncertainty, loss of loved ones, destruction of homes - all this creates serious pressure on the psyche of every person. At such moments, many people look for effective ways to reduce stress and anxiety.Numerous stress methods are increasing interest in natural remedies, one of which is the Amanita Muscaria fly agaric.Studies and their resultsA recent research conducted in 2023 by the National Research Center of Canada in cooperation with the Institute of Neuronuk and Mental Health of the University of Alberta showed that fly agaric red has a positive effect on microglia - brain cells, which play a key role in the regulation of neurosis processes.This research was published in Frontiers in Pharmacology, which confirms its scientific value.During the experiment, the HMC3 cell line was used, which simulates the reaction of human microgli to various stimuli. It was found that the extract of the fly agaric significantly reduces the level of inflammation in the brain, which often increases due to stress factors.Stress, especially chronic stress, activates microglia, which leads to neuroinflammation and can cause anxiety disorders and depression.Red amanita contains several active substances that affect the nervous system and help in the fight against stress.The main active substances of red fly agaric:Muscimol is the most powerful component of fly agaric, which acts on GABA receptors (gamma-aminobutyric acid), which is responsible for regulating the excitability of the nervous system. Muscimol has a soothing effect, similar to the action of traditional tranquilizers, but with fewer side effects. Ibotenic acid - this substance stimulates the recovery of brain cells after stress and damage. Ibothenic acid is able to activate neuroplasticity processes, which allows the brain to adapt to new conditions and restore function after traumatic events.Tregalose is a natural sugar that activates the process of autophagy, or cleansing cells from damaged components. In stressful situations autophagy plays an important role in maintaining cell health, especially neurons. Taglose is also capable of reducing inflammatory processes in the body that can be positively affected How does the fly agaric help to overcome stress?In the course of research, it was found that after receiving red fly agaric extract of proinflammatory cytokines (molecules that trigger inflammatory processes) decreased by 25% compared to the control group. In addition, amanita extract improves other important indicators of mental health:The anxiety has decreased by 30% compared to the control group, which indicates a strong anxiolytic (anti -alarm) effect of this fungus.The mood improved by 40% compared to people who did not take the extract. This is especially important in conditions of constant stress, because a positive mood makes it easier to experience difficult life situations.The mechanism of amanita's effect on the nervous systemNowadays, when every day brings new challenges and threats, our body is constantly in a state of "combat readiness". This causes excessive excretion of stress hormones such as cortisol, which adversely affect the work of the brain and the immune system. Chronic stress weakens our protective The fly agaric, thanks to its active components, helps to reduce this effect. Muscimol acts as a natural tranquilizer, soothing the nervous system and reducing the level of excitation. Ibothenic acid and trealose promote the restoration of brain cells and maintain their health, which is especially important during prolonged stress.Red toadstool is not just a mushroom, it is a powerful natural anti-stress agent that helps reduce anxiety, improve mood and reduce inflammation in the brain. Its active substances, such as muscimol, ibotenic acid and trehalose, have scientifically proven positive effects on mental health. Take care of your health and don't forget that the best way to overcome stress is to maintain a balance between physical and mental health. Natural remedies such as Red Amanita can be your reliable assistant in this.You can also buy them in our store.1.<a href='https://amanitamuscariastore.online/shop/amanita-muscaria-premium/'>Amanita fruits</a>2.<a href='https://amanitamuscariastore.online/shop/amanita-muscaria-capsules/'>Toadstool capsules</a>3.<a href='https://amanitamuscariastore.online/shop/amanita-muscaria-tincture/'>Amanita extract</a>4.<a href='https://amanitamuscariastore.online/shop/amanita-muscaria-powder/'>The fly agaric</a>

When is it safe to use the fly agaric of the new season?

Amanita Muscaria (Amanita Muscaria) contains active substances, such as ibotenic acid and muscimol. Two compounds play a different role in the influence of the fungus on the body.Ibotenic acid is a powerful toxin and neurotoxic compound that causes a number of unwanted effects such as nausea, hallucinations, and disorientation. This is why eating fresh or dried amanita mushrooms that are high in ibotenic acid is potentially dangerous to your health.Instead, muscimol, which is formed as a result of the transformation of ibotenic acid during drying (decarboxylation), has a more stable and mild effect on the body and is the subject of scientific research due to its potential in the treatment of stress, anxiety and psycho-emotional disorders.However, through the rush of consuming freshly picked mushrooms, people run the risk of getting more harm than good, because fresh fly agaric can lead to intoxication due to the high concentration of toxic compounds.Chemical transformation processIbotenic acid is unstable in drying and storage conditions, especially under the influence of heat and oxygen, which contributes to its decarboxylation to muscimol.During drying at a temperature of 40-45°C, intensive oxidation of ibotenic acid occurs, and its transformation into muscimol becomes more pronounced.This process is important because Muscimol, although it remains psychoactive, is safer to use, especially in the context of low doses used in therapeutic studies to reduce anxiety, ease stress and improve sleep quality.Scientific studies and recommendations for drying amanitaAccording to various studies, the process of decarboxylation of ibotenic acid to muscimol can take from several hours to several weeks, depending on the storage conditions. For example, drying amanitas in the sun or at low temperatures slows down this process and can leave a significant part of the toxic ibotenic acid in the mushrooms.Instead, drying the mushroom over wood at excessively high and constantly uneven temperatures causes the breakdown of muscimol and the mushroom loses its therapeutic effect. Studies show that long-term storage of dried mushrooms also contributes to a gradual decrease in the content of ibotenic acid, but these changes occur more slowly.For safe conversion of ibotenic acid, it is recommended to dry mushrooms at 40-45 ° C for 15-20 hours in a dehydrator and additionally store them for at least 1-2 months to maximize the conversion Risks of eating fresh or incorrectly dried mushroomsFresh or insufficiently dried fly agaric with high content of ibotenic acid pose a danger due to the possibility of toxic reactions and a psychoactive effect that is difficult to control. The consumption of such mushrooms can cause aggressive hallucinations, intoxication and serious gastrointestinal disorders. So the main conclusions:The active ingredients of the fly agaric: the red fly agaric contains ibotenic acid and muscimol, which have different effects on the body. Ibotenic acid is toxic, while muscimol has a more stable and softer effect after conversion.Risks in improper preparation: insufficiently dried mushrooms or drying at excessively high temperatures can lead to toxic effects or loss of medicinal properties of muscimol, so it is important to follow the recommendations for treatment and storage.In Ukraine, the amanita harvest season begins at the end of September - the beginning of October, so with proper storage and compliance with all the correct technological processes, the amanita of the new season can be safely consumed in mid-November, and preferably in early December.You can also buy them in our store.1.<a href='https://amanitamuscariastore.online/shop/amanita-muscaria-premium/'>Amanita fruits</a>2.<a href='https://amanitamuscariastore.online/shop/amanita-muscaria-capsules/'>A fly agaric capsules</a>3.<a href='https://amanitamuscariastore.online/shop/amanita-muscaria-tincture/'>Fly agaric extract</a>4.<a href='https://amanitamuscariastore.online/shop/amanita-muscaria-powder/'>The fly agaric</a>