Lion's Mane Against Depression: Properties and Mental Health Benefits

Depression is a common mental disorder characterized by persistent low mood, loss of interest in previously enjoyable activities, feelings of hopelessness, and other symptoms. It is a serious public health problem that affects millions of people worldwide.

Factors of depression:

The development of depression is associated with an imbalance of neurotransmitters in the brain, in particular serotonin, norepinephrine, and dopamine. These substances are responsible for regulating mood, emotions, sleep, and appetite. A decrease in their level can lead to depressive symptoms.

In addition, brain-derived neurotrophic factor (BDNF), a protein that promotes the growth and survival of neurons, plays an important role in the pathogenesis of depression. Decreased BDNF content in the brain is also associated with the development of depressive disorders.

The role of lion's mane in the fight against depression:

Lion's mane (Hericium erinaceus) is an edible medicinal mushroom that has long been used in traditional Eastern medicine. Modern research shows that extracts of this mushroom have powerful antidepressant properties.

Studies on animal models of depression have shown that the administration of Lion's Mane extract, enriched with the bioactive substance erinacin A, leads to:

1. Restoration of the level of monoamine neurotransmitters (serotonin, norepinephrine, dopamine) in the hippocampus - the area of ​​the brain responsible for emotions and memory.

2. Suppression of inflammatory processes in the brain by reducing the level of pro-inflammatory cytokines. Neuroinflammation is considered one of the factors in the development of depression.

3. Activation of BDNF/TrkB/PI3K/Akt/GSK-3β signaling pathways, which leads to increased expression of brain-derived neurotrophic factor (BDNF). This promotes neurogenesis (the formation of new nerve cells in the brain), improves neuroplasticity (the ability of neurons to change their structure and

The results of animal studies are supported by clinical observations. For example, in elderly people with mild cognitive impairment, taking Lion's Mane extract for 16 weeks improved cognitive functions and reduced symptoms of depression and anxiety.

Lion's mane demonstrates a multifaceted positive effect on the brain in depressive disorders. Its active components are able to restore the balance of neurotransmitters, counteract neuroinflammation and stimulate neurotrophic factors. This makes extracts of this mushroom a promising natural remedy for prevention and support in the complex treatment of depression.

You can also buy them in our store.
1. lion's mane fruits
2. lion's mane capsules
3. lion's mane extract

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