Alzheimer's Disease: A Global Neurological Challenge
Alzheimer's disease is a slowly progressive neurodegenerative disease that suffers more than 50 million people in the world. Alzheimer's tough gradually destroys brain cells, destroys memory, thinking and behavior skills. And, unfortunately, this disease is incurable today.How Lion's Mane Stimulates Nerve Growth Factor (NGF)
It is known that Hericium erinaceus has long been used in oriental traditional medicine to improve cognitive functions. The main existing compounds of this fungus, such as gericennes and erinacin, stimulate the production of nerve growth (NGF), which is critical to the health of neurons.Recent studies have shown that the use of a hedgehog of a comb in Alzheimer's disease promotes the growth and survival of nerve cells, improves cognitive functions, memory and ability to learn.
2009 Japan Clinical Trial: Cognitive Improvement Results
The first study was conducted in 2009 in Japan by scientists of the Hokuto Corporation laboratory. It was attended by men and women aged 50 to 80 years with mild cognitive disorders. Due to 16 weeks, participants took tablets with Hericium erinaceus powder or placecebo.The study found that the Hericium erinaceus group showed significant improvements in cognitive function, especially at weeks 8, 12, and 16, compared to the placebo group.Cognitive function indicators improved by 5-10% according to the specially developed Hasegawa Scale (HDS-R). For example, at week 16, 71.4% of participants in the Hericium erinaceus group showed significant improvement, Whereas the placebo group in only 6.7%. The female serious side effects after taking Hericium erinaceus were not detected.2020 Taiwan Study: Lion's Mane for Early Alzheimer's
The second study was conducted in Taiwan in 2020 by a team at the Biotechnology Research Institute, Grape King Bio Ltd. This study focused on evaluating improvements in cognitive function and other health indicators in people with early-onset Alzheimer's disease. Participants took Hericium erinaceus extract for 1 year.These studies confirm that Hericium erinaceus can be an effective tool for improving cognitive functions and prevention of Alzheimer's disease. The use of this fungus can help reduce the risk of disease and relieve its symptoms.
How Lion's Mane Slows Neurodegeneration
If you want to improve and maintain your brain health with natural remedies, you should pay attention to Hericium erinaceus.The key to Lion's Mane's effectiveness against Alzheimer's disease lies in its ability to upregulate NGF production in the brain. NGF is essential for the maintenance of cholinergic neurons — the brain cells most severely damaged in Alzheimer's disease. As these neurons degrade, patients experience the characteristic memory loss and cognitive decline of the disease. By continuously stimulating NGF synthesis, Lion's Mane actively supports the survival and repair of these neurons, potentially slowing the progression of neurodegeneration.
Hericenones and erinacins, the two main neuroactive compound classes unique to Lion's Mane, are small enough to cross the blood-brain barrier — a critical advantage over many larger molecules that cannot reach the central nervous system directly. This direct access to brain tissue is what makes Lion's Mane uniquely effective among medicinal mushrooms for neurological conditions.
Practical Guide to Using Lion's Mane for Brain Health
For individuals seeking to support cognitive health and reduce the risk of Alzheimer's disease, a daily supplementation protocol of 1–3 grams of Lion's Mane fruiting body extract is commonly recommended. Clinical studies have typically used 16-week to 12-month supplementation periods before evaluating cognitive outcomes, reflecting the gradual nature of neuroregeneration.Lion's Mane pairs particularly well with omega-3 fatty acids, B vitamins (especially B12 and folate), and antioxidant-rich foods — all of which support neuronal health through complementary mechanisms. For elderly individuals or those with early signs of cognitive decline, beginning a Lions Mane regimen early — before significant neurodegeneration has occurred — offers the greatest potential benefit.
You can also buy them in our store.
1.lion's mane fruits
2.The lion's mane capsules
3.lion's mane extract