Red amanita: Recovery after a stroke
Red amanita (Amanita muscaria) is known to many thanks to its bright appearance, but few people know that this mushroom can help in the treatment of serious diseases, in particular, recovery after a stroke. Thanks to its biologically active compounds, the red amanita mushroom is becoming the object of scientific research all over the world.
A stroke is a dangerous condition in which the blood supply to the brain is disrupted, which can lead to serious damage to the brain tissue. After a stroke, many patients face problems related to cognitive functions, motor skills and other important aspects of health.Modern medicine is constantly looking for new remedies in rehabilitation after this dangerous condition, and fly agaric red can be an important part of these innovations.
The main active compounds of red fly agaric are musciolus and ibotenic acid. The most interesting is Muscimol, which is a strong agonist of GABA receptors (gamma-aminobutyric acid)-the main inhibitory neurotransmitter in our brain. Because glutamate is an excitatory neurotransmitter - it damages brain cells in excess. Muscimol helps to balance this process, reducing the risk of further damage.
According to a study, under the guidance of Professor Richard Green and scientists from the United Kingdom and New Zealand, and published in Neuropharmacology in 2000, Muscimol was a neuroprotector that contributes to a significant improvement in the state of stroke.During experiments on animals, it was recorded that the introduction of muscimol after an ischemic stroke reduces brain tissue damage by 37% compared to the control group.In addition, there was a significant improvement in cognitive functions and a faster recovery of motor skills.
In the Amanita Muscaria, a fly agaric has improved such indicators as:
Histological changes — analysis of brain tissue damage after an ischemic attack. The introduction of muscimol led to a significant decrease in the degree of damage to neurons, which confirmed the neuroprotective properties of this substance.
Biochemical changes - there was a decrease in glutamate output, the main excitatory neurotransmitter, which plays a key role in cell damage during stroke. This reduces the further deterioration of brain tissue.
Motor functions - after treatment of the musicmole, the animal showed faster recovery of motor skills. This is an important indicator in rehabilitation after stroke, as many patients face difficulties in performing even the simplest movements.
The water content in the tissues is a reduction in brain swelling after the administration of muscimol. Brain tissue swelling is one of the biggest threats after a stroke, which can significantly worsen the patient's general condition and complicate recovery. Thanks to muscimol, this dangerous process is significantly reduced, which helps to avoid additional complications.
Another study conducted at Kyoto Prefectural University of Medicine in Japan found that muscimol significantly reduced neuronal damage caused by over-activation of NMDA receptors – receptors that are particularly important for learning, memory and nervous system development.This study was published in 1993 in the journal "Journal of Neurochemistry". On the course of experiment, neuroni of mice was exposed to toxic NMDA (N-methyl-D-aspartate), which causes cell death, similar to the process that occurs during a stroke in the brain stroke
Muscimol was able to reduce the leakage of lactate dehydrogenase (LDH), a marker of cell damage, by 50% compared to the control group. Also, in the presence of muscimol, the number of damaged cells was reduced by almost half.
According to research, muscimol activates GABA receptors, which leads to hyperpolarization of neurons, that is, a decrease in their excitability. This, in turn, reduces the entry of calcium into cells, the main cause of damage to neurons during a stroke. This protective mechanism can help reduce neuronal damage and
You can also buy them in our store.
1.Amanita fruits
2.Toadstool capsules
3.Fly agaric extract
4.The fly agaric
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